??????????? ?????? ?????? - ? ??????? ? ????????????????? ????????? ?????????? ???????????????????? ???????? ??? ??????? ???

Human study ? ??????? ? ????????????????? ????????? ?????????? ???????????????????? ???????? ??? ??????? ???

??????? ?.?.

????????? ????????????? ???????????????????? ???????? ??? ??????? ??????????? ??????? ?????? ?????????????? ???????? ? 2000 ????. ???? ???? ??????????? ? ???, ????? ??????? ???????? ????????? ? ????????????? ?????? ?? ???????? ????? ? ???????????? ??????? ????????. ??? ???? ???????? ??????? ???? ?????? ????????? ? ??????????: ??????? ?????? ???? ???????? ?? ????? ?????????????? ???????? ?????????????????? ?????????????? (??????????, ???????? ? ??.), ??????? ? ???? ??????? ??? ?????????? ????? ??????????? ?????????????? ??? ??????? ?????????????? ?????????. ?????? ????????????????? ?????????? ?? ????? ???? ?????????????? [1]. ?????? ??????????? ?????? ???????? ????????????? ?????? ??????? [4], ???? ? ?????????. ?????? ?????? ????????? ?????? ?? ?????????? ??????? G-CSF ? ??????? ???????????? ????????: ?????? [2] ? ??????? [3]. ??????, ? ????? ? ???? ?????? ????????????? ????? ????????????? ???? ????? ??????????? ?????????????: ????? ?????????? ??? ?? ?????????????? ????? ???????? ?????????????? ???????, ??????? ????????????????? ?????????????? ? ???????-????????? ???????.

????????, ??? ?????????? ??? ????? ? ?????????? ?????????? CD34+ ?????? ? ?????????????? ?????. ?????? ????????? ??????? ?? ?????????? ??? ??? ??????? ??? ?????? ? ????? ????????: ????????? ??????? ????????????? CD34+ ?????? ? ????????, ? ??? ????? ? ????? ?? ???????????????? ???????? [12]. ???????? ??????????? ????????????? ?????????? ?????? ? ???????? ????? ?? ??????????????? ??????????????, ????? ??????? ??????? ? ??????????? ???????? ??????????, ????????? ?????????, ? ????? ? ???????????????? ?????????????????? ????????? ??? [9].

??????? ???? ???????????? ?????????? ??????????? ????????????, ? ??????? ????????? ? ?????? ????????? ???????? ????? ??????????? ?????? ? ???????-????????? ??????? ? ??? ?? ????????????? ??????? ??????, ?????????? ????? ??????? ?????????????? ????? ????? ????? ?-???. ?????? ???????????? [5, 6] ??????????? ? ????? (Myocardial regeneration and Angiogenesis with G-CSF and Intra-Coronary stem Cell - MAGIC Cell), ?????? – ? ??????? [7].

????????? ????????????, ?????????? ??? ???????????? H.S.Kim, ????? ?????????? ????????. ???????? ? ??? ???? ????????? ?? 3 ??????: ?????? ?????? ???????? ??? ? ??????????????? ??????????????, ?????? – ?????? ???, ?????? – ??????????? (???. 1?). ??? ???????? ???????? ?????????? ??????????????? ??????? ? ????????? ????????? ?????? ? ???????-????????? ???????. ?????????, ??? ?????? ?????? ???? ????? ?? ????? ???????? ??????????? ??? ??????? ???????? (???????? 6,2% ?????? ?????????? ?? 4,3% ?? ?????? ??????) ? ???????? ????????????? ????? (???????? ?? 15,7% ?????? ??????????? ?? ?????? ??????). ??????????? ????? ???????????? ??????? ????? ?????????? ?????????, ????????? ?? ??????? ???????? ????????????? ???????? ??????? ????????? ??????????? ?? ??????????? ?????? (???. 1?). ? ????? ???? ????????? ??????? ????????????. ???? ????????, ??? ????? 6 ??????? ????? ??????????????? ?????????????? ???-??????????????? ?????? ????? ??????? ??????? ?????????? ????????????? ?? 7%, ???????? ????????????? ????? ?????????? ?????????? ????? ?? 17%. ? ??????????? ??????, ?????????? ???????????? ???????, ??? ? ?????? ?????????, ??? ? ? ?????? ?? ?????, ????????????? ??????? ?? ?????????? [8].

??????? ????????? ??????? ???????????? ????????? ?????????? ? ????? ??????: ?????????, ??? ? ?????? ? ??????????????? ?????? ? ?????? ???????????? ? ????????? ?????? ?????????? ????????? ?????????, ????? ??? ? ???????? ?????? ?????? ?? ?? ???? (??? ??????? ?? ??????????? ??????). ??? ???????? ??? ????????? ?? ?????????? ???????? ??????????????? ??????, ??????? ?????. ??? ???????? ?????? ??????????? ?????????????? F. Leisch et al., ?? ??? ???????? ????? ????????? ??????????. ?? 24 ?????????, ?????????? ??????? ????????????, ? ????? ????????? ??????? ?????? (????? 2,6 ? 14 ??????? ????? ?????????), ????? ??? ???? ????????????? ??????????, ??? ??? ??????????? ??????? ??? ???????? ??? ?????????? ????? ????? (???. 2).

???????? ???????? ? ???? ????????????. ?????? ????? ????????????? ? ??????????? ??????? ? ????????? ??????????? ????????? ?????????????? ??????? ?????? ? ?????????? ??????? (????? 6 ???????). ?????? ??????????? ?? ???? ????????????? ????????????? ? ??????????? ?????? ????????????? ??????? ?? ???????????. ???? ???????? ????, ???????, ????? ???? ?????? ?????? ????????? ????? ?????????, ?? ?????????? ?????????? ? ???????? ????????????? ???.

? ???? ????? ??????? ????????? 2 ??????, ?????????????? ? 2005 ???? ? Journal of the American College of Cardiology. ???????? ?? ??, ? ???? ????????????? ???? ????????, ??? ??-??? ? ?-??? ??????????? ??????????? ????? ?????????? ???????, ??? ??? ???? ?????????????? ??????????? ??-?? ????????? ???????????. ? ?????? S. Zbinden et al. [10], ??-??? ? ??????? ???? ?????? ????????? ? ????????? ?? ?????????? ???????????? ????? ??????????????. ? ??????? 12 ???? ????? ??????? ? ???? ?? ???? ??????????? ????????? ???????? ?????? ??????? ????????. ? ???????????? [11] 2 ?? 16 ????????? ? ???????????? ????????????, ?????????? ?-??? ? ??????? ???? ????, ????????? ?????? ??????? ????????, ???? ??????? ??? ???? ????.

????? ????, ?????? ?? ?????? ??? ????, ??? ????? ????? ?????????????????? ????????????, ???????????? ????????????? ????????? ???, ? ?? ????????????? ??? ??????? ?????? ????????????????? ??????????? ??? ???. ??????????, ?????? ???????????? ????? ??? ???????? ????????????? ? ???????????????? ?????? ???????????. ? ???? ???????? ?? ??? ?????????? ??????????, ? ??????? ?????? ??????????? ? ?????????????? ????????????? ??? ??? ??????? ????????? ???? ???. ?????????? ???????? ?????????????? ?????????? ?? ???? ????????, ????? ???????? ? ???????????? ????????????? ? ????????????? ????????? ????????? ????????? ??????? ??? ??? ???.

?? ??????????
Kang H.J., Kim Y.S., Koo B.K. et al. Effects of Stem Cell Therapy with G-CSF on Coronary Artery after Drug-Eluting Stent Implantation in Patients with Acute Myocardial Infarction. Heart. 2007. Dec 10. [Epub ahead of print].

Steinwender C., Hofmann R., Kypta A. et al. Late stent thrombosis after transcoronary transplantation of granulocyte-colony stimulating factor-mobilized peripheral blood stem cells following primary percutaneous intervention for acute myocardial infarction. International Journal of Cardiology. 2007:

??????????:

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