Дата: 2008-03-04 18:49
? ?????? ?????????????? ?????????????????? ??????? ? ????????? ? ?????????????? ?????????. ?????? ????????? ALLHAT.

???????? ?? ??????????????? ????????????? ????, ? ??????? ? ?????????????? ????????? (??) ? ???????? ?????????????????? ??????? ?????? ????? ????????????? ????????? ? ?????? ?????????????? ????????, ???????? ?????????? ???????????????????????? ???????? (????), ??????????? ?????????? ??????? (???) ??? α-?????????. ?????????????, ??????????? ?????????? ????????????????? ??????? ?????? ????????? ALLHAT*, ????????? ???????????? ?????? ??? ?????? ????????????? ????????????? ????????????? ??????? ???? ????????????, ??? ???????????, α-?????????? ???????????? ? ?????????? ?????????? ????????????? ? ????????? ? ??. ?? ??????????? ??? ??????? ???????????? ??????????? ? ????????? ? 2 ? ????? ?????????:

??????? ???????? ??????? ≥ 100 ??/?? (5,55 ?????/?), ?????? ????? ???? ≥ 30, ???????????? ????????????? ≥ 150 ??/?? (1,7 ?????/?) ? ????????????? ??????? ????????? < 40 ??/?? (1,04 ?????/?) ? ?????? ? < 50 ??/?? (1,3 ?????/?) ? ??????.
???????? ?? ???????? ? 54,4% (n=23 077) ?? 42 418 ?????????? ?????????. ?? 4 ???? ?????????? ??????? ?????? ??????????? (???????? ?????????? ???????? ???????????) ? ??????? ??????? ???????? ? ??????? ??????????, ??????????? ? ???????????, ??? ? ?????? ????????????. ? ??????? ????, ??? ? α-????????? ????? ??? ??????? ????????? ??????? ??????? ???????? ???????: ?????????????? ?? 6–7, 2–5 ? 8–13 ??/??, ??? ? ?????? ?????????. ??? ?? ?????, ???????????? ???????? ? ????????? ????????? ???????? ????? ????????? (??????????? ??????? ???????? ? ?????? ?? ?????????? ??????? ??????) ?? ????????. ????? ????, ? ????????? ?? ? ??????? ????, ??? ? α-????????? ??????? ????? ??????? ???? ???????? ????????? ??????????????? ? ????????? ? ?????????????. ??????????????? ????????????? ???? (??) ???????? ? ?????????? ????????? 1,49 (95% ????????????? ???????? – 1,17–1,90), 1,50 (1,18–1,90) ? 1,88 (1,42–
2,47); ? ????????? ??????? – 1,20 (1,01–1,41), 1,25 (1,06–1,47) ? 1,82 (1,51–2,19). ????? ??????? ???? ????? ????????-?????????? ????????? ??????? ??? ????????? ??????????? ? ???????????? (?? ? ?????? – 1,24 [1,09–1,40] ? ????????? – 1,10 [1,02–1,19]) ? ??????????? ? ???????????? (?????????????? ?? – 1,37 [1,19–1,58] ? 1,18 [1,08–
1,30]). ??????????? ???? ???????? ??????? ??? ????????? ???? ? ????????? ? (?? – 1,37 [1,07–1,76] ?????? ? ?????????? ?????????) ? α-????????? ? ????????? (?? – 1,49 [1,09–2,03]). ????? ????, ?????? ??????? ? ?????? ???? ????? ????? ??????? ???? ???????? ???????? ?????? ???????? ??????????????? ? ????????? ? ??????? ????????? (?? – 1,7 [1,13–2,55]).
????? ???????, ???????? ?? ????? ???????????????? ?????????????? ???????, ????, ??? ? α-???????? ????????? ?? ????? ???????????? ? ???????????? ???????? ????????-?????????? ? ???????? ???????, ??? ?????????? ???????? ??????????? ? ????????? ? ??, ???????? ??????????.
????????.
Wright Jr J.T., Harris-Haywood S., Pressel S. et al. Clinical Outcomes by Race in Hypertensive Patients With and Without the Metabolic Syndrome. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med. January 28, 2008;168(2):207-217.
??????-????????. Medline ????????.

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