Дата: 2008-05-11 11:11
?????? ?? ????????? Keio University School of Medicine ????????, ??? ???????? ???????????????? ????????????????????? ??????? (G-CSF) ????? ???????? ???????? ???????? ?????????????? ??????? ?????? ? ???????? ????????????.???????????? ??????????? ?? ?????. ????????? ?????????????? ???? ????????, ??? ???????? ? ?????? ????? ???????? ?????????? ?? ???????? ????? ?????????? c-kit(+) ???????? ??????????????? ? ??????? ??????. ??? ?????????? ???????? ?????? ????????, ?????? ?? ???????????? ???????? ?? ??????????????? ??????? ??????????????? ????????? ?????? ???????? ?????, ????? ??????? ? ???????? ????? ??????????????? ????????? G-CSF.

??? ?????????????? ????????? ????? ????????? ? ????????????????? ????? ???????????? ??????????????? ????????? ?????? (???) ?? ??????????? ??????? ??????? ?????????????? ?????? (GFP) ?????. ??? ????????? ? ?????????? ?????? ???????? ??? ? ?? ????????? ?? ?????? ??????. ????? ?? ????? ???????????? ??????? ???????? ? ? ??????? 10 ???? ????? ????? ??????? ?? G-CSF.

? ?????? ???? ? ??????? ???????? ??????????? ????????? ??????????????? ??????? ?????????????? ????? ?????? (GFP(+)) (?.?. ???????????? ?? ???) ????????????? ?????. ??????????? ???? ?????? ??????????????? ???????? ? ????? ??????? ???????????, ?? ?? CD45, ??? ??????? ? ???, ??? ??? ?????? ???????? ????????????????. ??? ???????? G-CSF ????? ????? ?????? ??????????? ??????????, ???????? ?????????????? ???????? ??????????? ????????????. ????????, ??? ????????? ? ????????? ??????????????? ? ??????? ?????? ? ????????? ????????????.

? ????????? ???????????? ?? ?????????????? ????? ??????????? GFP-????? ???????? ?????????????? G-CSF ???????? ? ??????? ?? ??????????? ?????????? ??????? ?????. ????? ????? ? ??????????????? ??????? ???????? ????? ????????? ????????? GFP(+) ???????????????.

?????????? ?????????? ??????? ? ????????????? ??????????????? ?????? ?? ?????????/?????????? ???????? ?????. ??????? ???????? ???????? ? ??????????? ???? ?????????, ??????? ? ??????? ???????? ???????????????? ? ??????????????. ???????? G-CSF ??????????? ????? ??????????? ? ? ?????????? ???????? ?????????????? ??????.

????????? ???????????? ???????????? ? ?????? Fujita J, et al. Administration of Granulocyte Colony-Stimulating Factor after Myocardial Infarction Enhances the Recruitment of Hematopoietic Stem Cell-Derived Myofibroblasts and Contributes to Cardiac Repair. Stem Cells. 2007 Aug 9; [Epub ahead of print]

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