? ??? ??? ?????? ??????????!
?????? ???????? ?????????? ???????, ?? ??? ?????????? ??????????? ? ??????????. ??? ???????? ????????? ??????????? ????? ??????????, ??? ??????? ? ?????????? ???????? ????? ??? ?????????? ?? ?????????? ???? ???????, ??? ?? ???? ?????? ????????.
???????. ???????????? ???????? ?????????? ???????? ? ????????????? ? ???????????? ? ????????????? ? ??????? ? ??????????????????? ?????????????
Study No. of Patients Follow-Up, y Comparison Absolute Risk Reduction,% P
CATS 1053 3 Ticlopidine vs placebo 4.5 0.006
TASS 3069 2–6 Ticlopidine vs aspirin 2 0.048*
CAPRIE† 6431 1–3 Clopidogrel vs aspirin 0.56 0.26
? ??????? ???????? ?????? ???????????? CAPRIE ? CATS ??? ???????? ??????? ? ??????????????????? ?????????????, ??? ???????????? TASS ????????? ??????? ???? ??? ?????????, ??? ? ??????????? ????????.
????????? ?????????? ? ?????? ?????? ???? ????? ????????? IIb/IIIa ?????????? ???????????. ??? ?????????????????? ????????????? ???????? ?? ?????? ??????????, ???????, ??????????, ? ???????????? ??????? ?????????. ?????? ?????????, ????????? ?? ?????? ?????????????? ??????? ????????? ???????????? ??? ??????????? ???????? ?? ????? ?????????? ?????????????. ?? ???????? ??????? ?? ????????? ????????? ?????????? ???????. ?????????? ?????????? ?????????, ?????????? ??? ???????? ?????? ?????? ???? ????????? ?????????????, ??? ????????????? ?????????????? ?????? ??????? ??????? ????????? ?? ??????????? ????? ??????????, ??????? ???????? ?? ?????????? ???? "?????????" ??????????. ?????? ??????????? ????? ?????????, ?????????? ? ?.?..
?????????? ?????????? ????????????? ???????? ?????????? -?????????? GPIIb/IIIa ?????????? ??? ?? ??????????. ??? ????????? ??????? ?????? ???????????? EPIC, IMPACT, EPILOG, CAPTURE, RESTORE, EPISTENT, PRISM, PRISM+, PARAGON, PURSUIT, ??????? ???????? 33,000 ???????, ???? ????????, ??? ?? 30 ???? ?????????? ???????? ????? (???????? ? ??????) ????????? ?? 21% ? ????????? ? ??????? ? ??? ???????? ???????????, ?? ??????? ????, ?? 6- ??????.
? ??? ?????????? ????????? ???? ????????????, ??????????? ? ?????? ? ????????? ??????????? ???????????????? ????????? ? ?????????
.????????????? ?????? ?????????? ? ????????????? ? ????????.
???????????? ????? ??????? ??????????(%)
??????? ?????
EXCITE 7232 1.0 1.35
OPUS 10302 1.4 1.95
SYMPHONY-1 9169 1.8 2.0
????? 26703 1.4 1.8
????????????? ?????? ??????? ??????? ? ????????? ???????? ????? ???????, ?????????? ? ???????????? ? ????????.
???????????? ????? ??????? ???????? ????? (%)
??????? ?????
EXCIT 7232 9.1 8.7
OPUS 10302 4.5 5.3
SYMPHONY-1 9169 7.0 7.7
????? 26703 6.6 7.0
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