??????? – ???????????, ???????????, ??????????, ???????????, ????????????, ???????????? – ???????? ??????????? ? ?????? ??????????? ???????? ???????????????????? ???????. ????????????????? ???????? ???? ?????????? ??????????? ?????????????? ?????????-?????????????-???-????????? – ???????? ??????? ??????????? (??) ?? ?????? ??????????? ??????????? ???????.

????????????? ???????? ???????? ?? ?????????????? ????????????????? ??????????? ????????????? (???). ?????? ???????????? – Scandinavian Simvastatin Survival Study (4S), Cholesterol and Recurrent Events (CARE), West of Scotland (WOSCOPS) [4, 5, 6] – ????????, ??? ??????? ????????? (????????????? ? ?????????????) ? ??????? ???? ??? ??????????? ??????? ??????? ????????-?????????? ?????????? ? ????????? ? ???????????????????? ? ???, ? ????? ?????????? ????????? ? ????????????? ??? ?????????????? ???. ????????????? ???? ?????? ?? ??? ??? ?????????? ???????????? ? ????????????? ?????????? ?? 42%; ???? ???????? ???????? ?????????? – ?? 34%; ??????????? ? ??????????????? ???????????? ??? ????????????? ?????????? ??????? – ?? 37%.

? ??????????? ??? – Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study [7, 8], Heart Protection Study [9, 10], Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) [11] ? Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) [12] – ???? ???????? ????????????? ???????? ? ?????? ????? ?????????, ??????? ??????? ???????? ????????; ? ?????????? ??? – Collaborative Atorvastatin Diabetes Study (CARDS) ???????? ?????? ???????????? ?????????? ???????? ?? ????????? ? ??????? ? ??????? ???????? ???????? ? ??????? ????????-?????????? ?????? [13].