?????????? ??? ???????????? / ??????? / ??????????? ??????

Дата: 2007-10-25 17:57

???????? ??????? ??????????: ????-?????? (Adverse effects of low dose amiodarone: a meta-analysis / Vorperian V R, Havighurst T C, Miller S, January C T.. Journal of the American College of Cardiology 1997; 30(3): 791-798.) ????????????? 4 ??????? ?????? ???????-?????????????? ???????????? (1465 ?????????: 738 - ????????? ? 727 - ???????). ????? ??????? ??????????? ?????????? ????????? ??????????????? ???????? ??? ?????????? ?????? ??? ?????????? ???? ???????: ?????????? ?????? - ????????? ??????? 4.2 (95 % ????????????? ????????: ?? 2.0 ?? 8.7), p=0.001; ?????????? - 2.0 (?? 1.1 ?? 3.7), p=0.02; ???? 2.5 (?? 1.1 ?? 6.2), p=0.05; ????? 3.4 (?? 1.2 ?? 9.6), ?=0.02; ??????????? 2.2 (?? 1.1 ?? 4.3), p=0.02. ??????? ???????????? ??????????? ?????? ?????????????? ???????? ? ?????? ?????????? ???? ?????????????? ? 1.5 ???? ????, ??? ? ?????? ??????? (1.52, ?? 1.2 ?? 1.9, p=0.003). ???????? ?????????? ? ?????????-???????? ??????? ??????????? ? ?????? ?????????? ? ?????? ???????? (1.2 (95 % ????????????? ????????: ?? 0.4 ?? 3.3), p=0.7 ? 1.1 (?? 0.7 ?? 1.9), p=0.678 ??????????????). ??????? ????????? ? ?????????? ??????? ?????????? ??????????? ?? ?????? 2.0 (?? 0.9 ?? 5.3), p=0.07.
?????? ?????????? ?????????????? ??????????????? (Outcomes from the use of the implantable cardiac defibrillator. / Hider P. New Zealand Health Technology Assessment (NZHTA) 1997 (NZHTA Report 1): 99.) ??????? ????????? ????? ????????? ? ??????????, ??? ICD ???????? ???????? ?????????, ??????? ????????? ? ????? ?? ???? ????? ???????? ????? ????????? ??????????? ??????. ??? ??????: ???????? ????? ????????? ??????; ??????? ? ??????? ?????? ??????????????? ??????????? ??? ? ???????? ? ???????? ??? ? ?????????????? ????????, ??? ????????? ??????, ???? ?? ????? ????????? ??? ????????? ?????????????? ?????? ??????????? ??? ????????????? ?????? ??????? ? ?????? ????? ??????????? ??????? ?????? ?/??? ?????? ??????? ??????? ?????? ?????????.
?????????? ? ??????? ??????????????? ?????????? ? ??????????? ?????????? (Propafenone for the treatment of supraventricular tachycardia and atrial fibrillation: a meta-analysis / Reimold S C, Maisel W H, Antman E M. American Journal of Cardiology 1998; 82: N66-N71.) ??????? 60 ????????????, ???????: ??????????? ??????????????? ?????????? - 8 ????????????, n=153 ????????; ??????????? ?????????? ??????????????? ?????????? - 6 ????????????, n=214 ?????????; ??????????? ??????????? ?????????? - 27 ????????????, n=1843 ????????; ? ?????????? ??????????? ?????????? - 25 ????????????, n=1105 ?????????. ?????????? ??????? ????????? 83.8 % (95 % ????????????? ????????: 78.1 - 89.7 %) ??????????????? ?????????? ? ????????? ?????????, ?????????? ?? ????????? ????? ??? ??????? ? ??????? 1 ???? ???? 64.6 % (95 %: 58.1 - 71.1). ??????????? ??????????? ?????????? ??????????? ?????????? ??????????? ? ??????? ?????, ?? 76.1 % (95 %: 72.8 % - 79.4 %) ????????? ?? ????????? ????? ????? 24 ???? ????? ?????? ???????. ????????, ?????????? ???????????? ???????, ????? ????????, ??????????????? ????????? ???? ? ?????? 4 ???? ????? ?????????? ?????????????? ????????. ???????????? ?????????? ??????????? ?????? ??????? ? ?????????????? ?????????? ????? ???? ????? ??????? ? ?????? 8 ????? ????? ?????? ??????? (???????????? ??????? ? ?????? 4 ???? - 31.5 %, 95 %: 24.5 - 38.5; ? ?????? 8 ????? - 32.9 %, 95 %: 24.3 - 41.5, p < 0.01). ??? ???????????? ??????? ??????????? ? 11.0 % (95 %: -0.6 - 22.4) ????? 24 ?????. ?????????? ??? ?????????? ? ?????????? ????????? ??????????? ?????????? ? 55.4 % (95 %: 51.3 % - 59.7 %) ??????? ? ??????? 6 ??????? ? 56.8 % (95 %: 52.3 - 61.3) ? ??????? 12 ???????.

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