?????????-??????????????? ??????????????? ???????: ????? (Amiodarone-associated proarrhythmic effects: a review with special reference to Torsade de Pointes Tachy-cardia / Hohnloser S H, Klingenheben T, Singh B N. Annals of Internal Medicine 1994; 121(7): 529-535.) ????????? 6 ???????? ??????? (? ?????????? ? 59 ???????????? ? ?????? 1989 ????), 17 ?????????????? ???????????? ? 7 ???????-?????????????? ????????????. ?? ?????? ??????? ???????? torsade de pointes ?? ???? ?????? ?????????? ?????????????? ?????? ????????????????? ???????. ?? 2878 ????????? ? ???????????????? ????????????? ? 2 % ??????????? ??????????????? ???????, ??????? 0.7 % torsade de pointes. ? 7 ???????-?????????????? ????????????? ?????????? ?????????? ?? ???? ??????? ? ????????? ??????????????? ???????. ????????? ?????? ? ?????? ?????? ??????????????? ??????? (??????? torsade de pointes), ????????????? ????? ??? ? 1 % ???????.
???????????????? ?????? ?????????? ????? ??????? ???????? ???????? ? ??? ??????????? ??????????????? ??????????????: ????-?????? (Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of indi-vidual data from 6500 patients in randomised trials / Amiodarone Trials Meta-Analysis Investigators. The Lancet 1997; 350: 1417-1424.) ??????? ?????? ????????????????? ?????????????? ???????????? ?????????, ??????? ?????????? ??????? ???????? (5101 ???????); ?? ??? 6 ???? ???????? ??????? ???????-??????????????? ? ???? ????????????????? ?????????????? ???????????? ????????? ? ??????????? ????????? ???????????????? (1452 ????????); ?? ??? 3 ???? ???????? ??????? ???????-???????????????. ???????????????? ????? ?????????? ??????? ??????? ???????????? / ????????? ?????? ? ????????? ? ??????? ?????? ? ???????? ????????? ???????? ??? ????????? ????????? ???????????????? ? ???????? ? ???????? ?? 13 % ????? ??????????.
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