?????????? ??? ???????????? / ??????? / ??????????? ?? ??????? ????????? ? ???????????? ??????????

Дата: 2007-10-25 18:04

?????? ??: Pearce et al., Assessment of these schemes for stratifying stroke risk in patients with nonvalvular atrial fibrillation. Am J Med 2000;109:45-51.
(1) - Circulation 1997;96:2617-24.
(2) Ann Intern Med 1996;124:970-9.
(3) N Engl J Med 1993;328:148, N Engl J Med 1992;327:1406-12.
??????? 19. ?????????????????? ??????? ?? ?????? ?????? ????? ? ????????? ? ??.
????????? ??????? ?????????????????? ??????? ????? ????????????
?????? 60 ???, ??? ??????????? ?????? (????????????? ??) ??????? 325 ??/??? ??? ??? ??????? I
?????? 60 ???, ???? ??????????? ??????, ?? ??? ???????? ?????* ??????? 325 ??/??? I
??????? 60 ??? ? ??????, ?? ??? ???????? ?????* ??????? 325 ??/??? I
??????? 60 ??? ? ??????, ??????? ???????? ?????? ??? ??? ??????????? ?????????????? (??? 2,0 - 3,0) I
????????????? ??????? 81 - 162 ??/??? II b
??????? 75 ??? ? ??????, ???????? ??????? ??????????? ?????????????? (??? ~ 2,0) I
??? ??????????? ?????????????? (??? 2,0 - 3,0) I
??????? ??????? ?? ?? ???? 35%, ?????????????, ???????????
????????????? ????????? ?????? (?????????? ??????) ??????????? ?????????????? (??? 2,5 - 3,5 ? ????) I
????????????? ?????? ??????
????????????? ? ????????
????????????? ??????? ? ??????????? ??? ?? ?????

* ??????? ????? ?????????????: ???, ??????? ??????? ?? ????? 35%, ? ??????????? ? ????????.
????? ???????????? I - ?????, ??????????, ???????????.
????? ???????????? II b - ?????, ?? ?? ?????????????.
2. ???????????????? ????????? ??? ???????????? ???????????? ???????? ? ????????? ???????
??????? 20. ???????????? ?????????????????? ??????? ? ????????? ? ??????????? ??.
Trials ??? ?????????? ????? ??????? ????????? ?????????
???????, ?????????????? Trials
Copenhagen Atrial Fibrillation, Aspirin, Anticoagulation I (AFASAK I) 1989 1,007 OA, ASA, placebo
Copenhagen Atrial Fibrillation, Aspirin, Anticoagulation II (AFASAK II) 1998 677 OA, ASA, OA*+ASA, OA*
Stroke Prevention in Atrial Fibrillation I (SPAF I) 1991 1,330 OA, ASA, placebo
Stroke Prevention in Atrial Fibrillation II (SPAF II) 1994 1,100 OA, ASA
Stroke Prevention in Atrial Fibrillation III (SPAF III) 1996 1,044 OA, OA*+ASA
Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) 1990 420 OA, control
Canadian Atrial Fibrillation Anticoagulation (CAFA) 1991 378 OA, placebo
Stroke Prevention in Nonrheumatic Atrial Fibrillation (SPINAF) 1992 571 OA, placebo
European Atrial Fibrillation Trial (EAFT) 1993 1,007 OA, ASA, placebo
Studio Italiano Fibrillazione Atriale (SIFA) 1997 916 OA, indobufen
Minidose Warfarin in Nonrheomatic Atrial Fibrillation 1998 303 OA, OA*
Prevention of Arterial Thromboembolism in Atrial Fibrillation (PATAF) 1999 729 OA, OA*, ASA
????????? ??? ???????? Trials
Harenberg et al. 1993 75 LMW heparin, control
Low-dose Aspirin, Stroke, Atrial Fibrillation (LASAF) 1996 285 ASA, placebo
????????? ? ?? ? ?????? Trials
European Stroke Prevention Study II (ESPS II) 1997 429 ASA, dipyridamole, placebo
?????????????? ??? ???????????????? Trials
French Aspirin Coumarin Collaborative Study ... ... OA, OA+ASA
Swedish Atrial Fibrillation Trial ... ... ...
Stroke Prevention using an Oral Thrombin Inhibitor in Atrial Fibrillation (SPORTIF) ... ... OA, thrombin in-hibitor

OA - ??????????? ??????????????, ??* - ?????? ????, ASA - ???????, LMW - ?????????????????
???????????? ?? ?????????????????? ??????? ? ????????? ? ??
????? I
1.????????? ?????????????????? ??????? (??????????? ?????????????? ??? ???????) ???? ????????? ? ??, ????? ??????? ? ????????? ??, ??? ???????????? ?????????????. (??????? ?????????????: A)
2.??????????????????? ????? ??????????????????? ?????????, ?? ?????? ??????????? ????? ???????? ? ????????????, ? ????? ????????? ????? ? ?????? ??? ??????? ????????. (??????? ?????????????: A)
3.??????????? ??????????? ???????????????? ??????? ? ????, ??????????? ?? ?????????? ??? 2-3 ? ????????? ? ??????? ?????? ????????, ???? ??? ????????????????. (??????? ?????????????: A)
a.??????????? ? ??????????????? ?????? ????????? ???????? ???????????????. (??????? ?????????????: A)
b.??? ?????? ???????????? ?? ??????? ???? ??????????? ? ??????? ?????? ?????????????? ? ??????????, ????? ??????? ????????. (??????? ?????????????: A)
4.????????? ??????? ? ???? 325 ?? ????????? ??? ???????????? ? ????????? ? ?????? ?????? ??? ? ????????? ? ?????????????????? ? ??????????? ??????????????. (??????? ?????????????: A)
5.????????? ??????????? ?????????????? ????????? ? ??, ??????? ????? ????????????? ????? ??????????? ??????? ??? ??????? ????????? ???????? (???????????? ??? ????????). (??????? ?????????????: B)
a.?????????? ??????? ????????????? ?????????????? ?? ???? ???????, ?? ?? ?????? ??? ??? 2 - 3. (??????? ?????????????: B)
????? IIa
1.???? - ????? ?????? ???~2 (1.6-2.5) ??? ????????? ???????????? ???????????? ???????? ? ????????? ??????? ? ????????? ?????? 75 ??? ? ?????????? ?????? ????????????, ?? ??? ????? ???????????????? ? ??????? ????????????????. (??????? ?????????????: C)
2.????????? ?????????????????? ??????? ????????? ? ??????????? ??????????, ? ????? ??? ??, ??? ? ????????? ? ?? (??????? ?????????????: C)
3.???????? ?????????????????? ???????, ????????? ???? ? ?? ?? ????????, ?????????? ?? ???? ?? (?? ????, ??? ????????? ? ???????????????, ???????????? ? ??????????? ??). (??????? ?????????????: B)

Наверх страницы